Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses

There is evidence that viral oncolysis is synergistic with immune checkpoint inhibition in cancer therapy but the underlying mechanisms are unclear. Here, we investigated whether local viral infection of malignant tumors is capable of overcoming systemic resistance to PD-1-immunotherapy by modulatin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Ther
Päätekijät: Woller, Norman, Gürlevik, Engin, Fleischmann-Mundt, Bettina, Schumacher, Anja, Knocke, Sarah, Kloos, Arnold M, Saborowski, Michael, Geffers, Robert, Manns, Michael P, Wirth, Thomas C, Kubicka, Stefan, Kühnel, Florian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817928/
https://ncbi.nlm.nih.gov/pubmed/26112079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.115
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