PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival

70–90% of low-grade gliomas and secondary glioblastomas are characterized by mutations in isocitrate dehydrogenase 1 (IDHmut). IDHmut produces the oncometabolite 2-hydroxyglutarate (2HG), which drives tumorigenesis in these tumors. The phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Batsios, Georgios, Viswanath, Pavithra, Subramani, Elavarasan, Najac, Chloe, Gillespie, Anne Marie, Santos, Romelyn Delos, Molloy, Abigail R., Pieper, Russell O., Ronen, Sabrina M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642106/
https://ncbi.nlm.nih.gov/pubmed/31324855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47021-x
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