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Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

Activation of the unfolded protein response (UPR)-associated transcription factor ATF6 has emerged as a promising strategy to reduce the secretion and subsequent toxic aggregation of destabilized, amyloidogenic proteins implicated in systemic amyloid diseases. However, the molecular mechanism by whi...

詳細記述

保存先:
書誌詳細
出版年:Cell Chem Biol
主要な著者: Plate, Lars, Rius, Bibiana, Nguyen, Bianca, Genereux, Joseph C., Kelly, Jeffery W., Wiseman, R. Luke
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642020/
https://ncbi.nlm.nih.gov/pubmed/31105062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.001
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