Pharmacokinetics of adjusted-dose 8-hourly lopinavir/ritonavir in HIV-infected children co-treated with rifampicin

OBJECTIVES: To evaluate the proportion of children with lopinavir C(min) ≥1 mg/L when receiving a novel 8-hourly lopinavir/ritonavir dosing strategy during rifampicin co-treatment. METHODS: HIV-infected children on lopinavir/ritonavir and rifampicin were enrolled in a prospective pharmacokinetic stu...

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Bibliographic Details
Published in:J Antimicrob Chemother
Main Authors: Rabie, Helena, Rawizza, Holly, Zuidewind, Peter, Winckler, Jana, Zar, Heather, Van Rie, Annelies, Wiesner, Lubbe, McIlleron, Helen
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6640304/
https://ncbi.nlm.nih.gov/pubmed/31081020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz171
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