The Safety, Effectiveness and Concentrations of Adjusted Lopinavir/Ritonavir in HIV-Infected Adults on Rifampicin-Based Antitubercular Therapy

OBJECTIVE: Rifampicin co-administration dramatically reduces plasma lopinavir concentrations. Studies in healthy volunteers and HIV-infected patients showed that doubling the dose of lopinavir/ritonavir (LPV/r) or adding additional ritonavir offsets this interaction. However, high rates of hepatotox...

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Autores principales: Decloedt, Eric H., Maartens, Gary, Smith, Peter, Merry, Concepta, Bango, Funeka, McIlleron, Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3296695/
https://ncbi.nlm.nih.gov/pubmed/22412856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032173
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