Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin

AIMS: Rifampicin, a key component of antitubercular treatment, profoundly reduces lopinavir concentrations. The aim of this study was to develop an integrated population pharmacokinetic model accounting for the drug–drug interactions between lopinavir, ritonavir and rifampicin, and to evaluate optim...

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Detalhes bibliográficos
Main Authors: Zhang, Chao, Denti, Paolo, Decloedt, Eric, Maartens, Gary, Karlsson, Mats O, Simonsson, Ulrika S H, McIlleron, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403203/
https://ncbi.nlm.nih.gov/pubmed/22126409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04154.x
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