Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin

AIMS: Rifampicin profoundly reduces lopinavir concentrations. Doubled doses of lopinavir/ritonavir compensate for the effect of rifampicin in adults, but fail to provide adequate lopinavir concentrations in young children on rifampicin-based antituberculosis therapy. The objective of this study was...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Chao, Denti, Paolo, Decloedt, Eric H, Ren, Yuan, Karlsson, Mats O, McIlleron, Helen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2013
Gaiak:
Pharmacokinetics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853533/
https://ncbi.nlm.nih.gov/pubmed/23432610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12101
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