Pharmacokinetics of Lopinavir in HIV-Infected Adults Receiving Rifampin with Adjusted Doses of Lopinavir-Ritonavir Tablets

Rifampin coadministration dramatically reduces plasma lopinavir (LPV) concentrations. In healthy volunteers, doubling the dose of a lopinavir-ritonavir (LPV/r) capsule formulation overcame this interaction, but a subsequent study of double doses of the tablet formulation was stopped early owing to h...

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Bibliographic Details
Main Authors: Decloedt, Eric H., McIlleron, Helen, Smith, Peter, Merry, Concepta, Orrell, Catherine, Maartens, Gary
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122443/
https://ncbi.nlm.nih.gov/pubmed/21537021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01598-10
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