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Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma
BACKGROUND: Sorafenib is the first-line treatment for advanced-stage hepatocellular carcinoma (HCC). Several studies have shown that the up-regulation of β-catenin plays a role in sorafenib resistance in HCC; however, the mechanism associated with this phenomenon remains elusive. METHODS: Western bl...
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| Udgivet i: | J Exp Clin Cancer Res |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6639974/ https://ncbi.nlm.nih.gov/pubmed/31319849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1311-z |
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