Shc3 promotes hepatocellular carcinoma stemness and drug resistance by interacting with β-catenin to inhibit its ubiquitin degradation pathway

Hepatocellular carcinoma (HCC) is one of the most common cancers with an insidious onset, strong invasiveness, insensitivity to chemotherapy, and poor prognosis, thus makes clinical treatment challenging. The mechanisms require further elucidation for developing novel therapies and targeting drug re...

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Vydáno v:Cell Death Dis
Hlavní autoři: Liu, Yun, Zhuang, Hao, Cao, Fang, Li, Jie, Guo, Yan, Zhang, Jun, Zhao, Qiang, Liu, Yuanyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961052/
https://ncbi.nlm.nih.gov/pubmed/33723262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03560-8
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