Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma

MYH9 has dual functions in tumors. However, its role in inducing tumor stemness in hepatocellular carcinoma (HCC) is not yet determined. Here, we found that MYH9 is an effective promoter of tumor stemness that facilitates hepatocellular carcinoma pathogenesis. Importantly, targeting MYH9 remarkably...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Lin, Xian, Li, Ai-min, Li, Yong-Hao, Luo, Rong-Cheng, Zou, Yu-Jiao, Liu, Yi-Yi, Liu, Chen, Xie, Ying-Ying, Zuo, Shi, Liu, Zhan, Liu, Zhen, Fang, Wei-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018736/
https://ncbi.nlm.nih.gov/pubmed/32296025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-0111-4
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