HBX-induced miR-5188 impairs FOXO1 to stimulate β-catenin nuclear translocation and promotes tumor stemness in hepatocellular carcinoma

Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis, chemoresistance and patient prognosis in hepatocellular carcinoma (HCC). The role of miR-5188 in cancer stemness has never been documented. In this study, we investigated the clinical and biological roles of mi...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Lin, Xian, Zuo, Shi, Luo, Rongcheng, Li, Yonghao, Yu, Guifang, Zou, Yujiao, Zhou, Yan, Liu, Zhan, Liu, Yiyi, Hu, Yingying, Xie, Yingying, Fang, Weiyi, Liu, Zhen
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831466/
https://ncbi.nlm.nih.gov/pubmed/31695788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.37717
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