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Divergent Effects of a Transient Corticosteroid Therapy on Virus-Specific Quiescent and Effector CD8(+) T Cells

We investigated the influence of a transient treatment of corticosteroid on CD8(+) T cells during herpesvirus infection. Dexamethasone, a synthetic corticosteroid, induced apoptosis of naïve and memory CD8(+) T cells but virus-specific effector cells were spared. CD8(+) T cell susceptibility was dir...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kumar, Dhaneshwar, Sehrawat, Sharvan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639716/
https://ncbi.nlm.nih.gov/pubmed/31354707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01521
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