Surface Plasmon Resonance Reveals Direct Binding of Herpes Simplex Virus Glycoproteins gH/gL to gD and Locates a gH/gL Binding Site on gD

Herpes simplex virus (HSV) requires fusion between the viral envelope and host membrane. Four glycoproteins, gD, gH/gL, and gB, are essential for this process. To initiate fusion, gD binds its receptor and undergoes a conformational change that hypothetically leads to activation of gH/gL, which in t...

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Vydáno v:J Virol
Hlavní autoři: Cairns, Tina M., Ditto, Noah T., Atanasiu, Doina, Lou, Huan, Brooks, Benjamin D., Saw, Wan Ting, Eisenberg, Roselyn J., Cohen, Gary H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6639271/
https://ncbi.nlm.nih.gov/pubmed/31092568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00289-19
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