Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

Glucose is the ultimate substrate for most brain activities that use carbon, including synthesis of the neuro-transmitters glutamate and γ-aminobutyric acid via mitochondrial tricarboxylic acid (TCA) cycle. Brain metabolism and neuronal excitability are thus interdependent. However, the principles t...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Transl Med
मुख्य लेखकों: Jakkamsetti, Vikram, Marin-Valencia, Isaac, Ma, Qian, Good, Levi B., Terrill, Tyler, Rajasekaran, Karthik, Pichumani, Kumar, Khemtong, Chalermchai, Hooshyar, M. Ali, Sundarrajan, Chandrasekhar, Patel, Mulchand S., Bachoo, Robert M., Malloy, Craig R., Pascual, Juan M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637765/
https://ncbi.nlm.nih.gov/pubmed/30787166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan0457
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