Real-time hyperpolarized (13)C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers

The pyruvate dehydrogenase complex (PDH) critically regulates carbohydrate metabolism. Phosphorylation of PDH by one of the pyruvate dehydrogenase kinases 1–4 (PDK1–4) decreases the flux of carbohydrates into the TCA cycle. Inhibition of PDKs increases oxidative metabolism of carbohydrates, so targe...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Sharma, Gaurav, Wu, Cheng-Yang, Wynn, R. Max, Gui, Wenjun, Malloy, Craig R., Sherry, A. Dean, Chuang, David T., Khemtong, Chalermchai
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848094/
https://ncbi.nlm.nih.gov/pubmed/31712597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52952-6
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