Real-time hyperpolarized (13)C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers

The pyruvate dehydrogenase complex (PDH) critically regulates carbohydrate metabolism. Phosphorylation of PDH by one of the pyruvate dehydrogenase kinases 1–4 (PDK1–4) decreases the flux of carbohydrates into the TCA cycle. Inhibition of PDKs increases oxidative metabolism of carbohydrates, so targe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sharma, Gaurav, Wu, Cheng-Yang, Wynn, R. Max, Gui, Wenjun, Malloy, Craig R., Sherry, A. Dean, Chuang, David T., Khemtong, Chalermchai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848094/
https://ncbi.nlm.nih.gov/pubmed/31712597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52952-6
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