Real-time hyperpolarized (13)C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers

The pyruvate dehydrogenase complex (PDH) critically regulates carbohydrate metabolism. Phosphorylation of PDH by one of the pyruvate dehydrogenase kinases 1–4 (PDK1–4) decreases the flux of carbohydrates into the TCA cycle. Inhibition of PDKs increases oxidative metabolism of carbohydrates, so targe...

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Publicat a:Sci Rep
Autors principals: Sharma, Gaurav, Wu, Cheng-Yang, Wynn, R. Max, Gui, Wenjun, Malloy, Craig R., Sherry, A. Dean, Chuang, David T., Khemtong, Chalermchai
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848094/
https://ncbi.nlm.nih.gov/pubmed/31712597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52952-6
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