Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

Sinus node dysfunction (SND) and atrial fibrillation (AF) often coexist; however, the molecular mechanisms linking both conditions remain elusive. Mutations in the homeobox-containing SHOX2 gene have been recently associated with early-onset and familial AF. Shox2 is a key regulator of sinus node de...

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Vydáno v:Front Genet
Hlavní autoři: Hoffmann, Sandra, Paone, Christoph, Sumer, Simon A., Diebold, Sabrina, Weiss, Birgit, Roeth, Ralph, Clauss, Sebastian, Klier, Ina, Kääb, Stefan, Schulz, Andreas, Wild, Philipp S., Ghrib, Adil, Zeller, Tanja, Schnabel, Renate B., Just, Steffen, Rappold, Gudrun A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637028/
https://ncbi.nlm.nih.gov/pubmed/31354791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00648
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