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Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

Sinus node dysfunction (SND) and atrial fibrillation (AF) often coexist; however, the molecular mechanisms linking both conditions remain elusive. Mutations in the homeobox-containing SHOX2 gene have been recently associated with early-onset and familial AF. Shox2 is a key regulator of sinus node de...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Hoffmann, Sandra, Paone, Christoph, Sumer, Simon A., Diebold, Sabrina, Weiss, Birgit, Roeth, Ralph, Clauss, Sebastian, Klier, Ina, Kääb, Stefan, Schulz, Andreas, Wild, Philipp S., Ghrib, Adil, Zeller, Tanja, Schnabel, Renate B., Just, Steffen, Rappold, Gudrun A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637028/
https://ncbi.nlm.nih.gov/pubmed/31354791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00648
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