Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

Sinus node dysfunction (SND) and atrial fibrillation (AF) often coexist; however, the molecular mechanisms linking both conditions remain elusive. Mutations in the homeobox-containing SHOX2 gene have been recently associated with early-onset and familial AF. Shox2 is a key regulator of sinus node de...

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發表在:Front Genet
Main Authors: Hoffmann, Sandra, Paone, Christoph, Sumer, Simon A., Diebold, Sabrina, Weiss, Birgit, Roeth, Ralph, Clauss, Sebastian, Klier, Ina, Kääb, Stefan, Schulz, Andreas, Wild, Philipp S., Ghrib, Adil, Zeller, Tanja, Schnabel, Renate B., Just, Steffen, Rappold, Gudrun A.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Genetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6637028/
https://ncbi.nlm.nih.gov/pubmed/31354791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00648
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