Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling

GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium to injury from exposure to nutritional excess and ischemia/reperfusion injury. This phenotype is associated with the reduced acetylation of metabolic...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Manning, Janet R., Thapa, Dharendra, Zhang, Manling, Stoner, Michael W., Traba, Javier, Corey, Catherine, Shiva, Sruti, Sack, Michael N., Scott, Iain
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636327/
https://ncbi.nlm.nih.gov/pubmed/31138772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190302
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