Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions

The mitochondrial acetyltransferase‐related protein GCN5L1 controls the activity of fuel substrate metabolism enzymes in several tissues. While previous studies have demonstrated that GCN5L1 regulates fatty acid oxidation in the prediabetic heart, our understanding of its role in overt diabetes is n...

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Publicado en:Physiol Rep
Autores principales: Thapa, Dharendra, Zhang, Manling, Manning, Janet R., Guimarães, Danielle A., Stoner, Michael W., Lai, Yen‐Chun, Shiva, Sruti, Scott, Iain
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487468/
https://ncbi.nlm.nih.gov/pubmed/31033247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14054
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