IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Rationale: Acute respiratory distress syndrome is defined by the presence of systemic hypoxia and consequent on disordered neutrophilic inflammation. Local mechanisms limiting the duration and magnitude of this neutrophilic response remain poorly understood. Objectives: To test the hypothesis that d...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Harris, Alison J., Mirchandani, Ananda S., Lynch, Ruairi W., Murphy, Fiona, Delaney, Liam, Small, Donna, Coelho, Patricia, Watts, Emily R., Sadiku, Pranvera, Griffith, David, Dickinson, Rebecca S., Clark, Eilidh, Willson, Joseph A., Morrison, Tyler, Mazzone, Massimilliano, Carmeliet, Peter, Ghesquiere, Bart, O’Kane, Cecilia, McAuley, Danny, Jenkins, Steve J., Whyte, Moira K. B., Walmsley, Sarah R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635795/
https://ncbi.nlm.nih.gov/pubmed/30849228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201808-1599OC
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