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Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in vivo
The central regulator of the Wnt/β-catenin pathway is the Axin/APC/GSK3β destruction complex (DC), which, under unstimulated conditions, targets cytoplasmic β-catenin for degradation. How Wnt activation inhibits the DC to permit β-catenin-dependent signaling remains controversial, in part because th...
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| Publicado no: | Development |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6633605/ https://ncbi.nlm.nih.gov/pubmed/31189665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.164145 |
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