Low Nociceptor GRK2 Prolongs Prostaglandin E(2) Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase Cε, and MEK/ERK

Hyperexcitability of peripheral nociceptive pathways is often associated with inflammation and is an important mechanism underlying inflammatory pain. Here we describe a completely novel mechanism via which nociceptor G-protein-coupled receptor kinase 2 (GRK2) contributes to regulation of inflammato...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Eijkelkamp, Niels, Wang, Huijing, Garza-Carbajal, Anibal, Willemen, Hanneke L. D. M., Zwartkruis, Fried J., Wood, John N., Dantzer, Robert, Kelley, Keith W., Heijnen, Cobi J., Kavelaars, Annemieke
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633564/
https://ncbi.nlm.nih.gov/pubmed/20861385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3142-10.2010
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