G Protein–Coupled Receptor Kinase 6 Acts as a Critical Regulator of Cytokine-Induced Hyperalgesia by Promoting Phosphatidylinositol 3-Kinase and Inhibiting p38 Signaling

The molecular mechanisms determining magnitude and duration of inflammatory pain are still unclear. We assessed the contribution of G protein–coupled receptor kinase (GRK)-6 to inflammatory hyperalgesia in mice. We showed that GRK6 is a critical regulator of severity and duration of cytokine-induced...

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Detalhes bibliográficos
Main Authors: Eijkelkamp, Niels, Heijnen, Cobi J, Carbajal, Anibal Garza, Willemen, Hanneke L D M, Wang, Huijing, Minett, Michael S, Wood, John N, Schedlowski, Manfred, Dantzer, Robert, Kelley, Keith W, Kavelaars, Annemieke
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388142/
https://ncbi.nlm.nih.gov/pubmed/22331028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00398
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