Tumor Necrosis Factor-α (TNF-α) Regulates Shedding of TNF-α Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection

Tumor necrosis factor α (TNF-α) is a potent cytokine in neurodegenerative disorders, but its precise role in particular brain disorders is ambiguous. In motor neuron (MN) disease of the mouse, exemplified by the model wobbler (WR), TNF-α causes upregulation of the metalloprotease-disintegrin ADAM8 (...

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Gepubliceerd in:J Neurosci
Hoofdauteurs: Bartsch, Jörg W., Wildeboer, Dirk, Koller, Garrit, Naus, Silvia, Rittger, Andrea, Moss, Marcia L., Minai, Yuji, Jockusch, Harald
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633558/
https://ncbi.nlm.nih.gov/pubmed/20826683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1520-10.2010
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