The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells

BACKGROUND: Despite multimodal treatment, glioblastoma (GBM) therapy with temozolomide (TMZ) remains inefficient due to chemoresistance. Matrix metalloproteinase (MMP) and a disintegrin and metalloprotease (ADAM), increased in GBM, could contribute to chemoresistance and TMZ-induced recurrence of gl...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Dong, Fangyong, Eibach, Michael, Bartsch, Jörg W., Dolga, Amalia M., Schlomann, Uwe, Conrad, Catharina, Schieber, Susanne, Schilling, Oliver, Biniossek, Martin L., Culmsee, Carsten, Strik, Herwig, Koller, Garrit, Carl, Barbara, Nimsky, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648299/
https://ncbi.nlm.nih.gov/pubmed/25825051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov042
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