p75NTR Regulates Aβ Deposition by Increasing Aβ Production But Inhibiting Aβ Aggregation with Its Extracellular Domain

Accumulation of toxic amyloid-β (Aβ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease (AD). The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity; however, its role in the development of AD remains to be clarified. Th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Wang, Yan-Jiang, Wang, Xin, Lu, Jian-Jun, Li, Qiao-Xin, Gao, Chang-Yue, Liu, Xiao-Hong, Sun, Yin, Yang, Miao, Lim, Yoon, Evin, Genevieve, Zhong, Jin-Hua, Masters, Colin, Zhou, Xin-Fu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633040/
https://ncbi.nlm.nih.gov/pubmed/21307265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2733-10.2011
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge