p75NTR Regulates Aβ Deposition by Increasing Aβ Production But Inhibiting Aβ Aggregation with Its Extracellular Domain

Accumulation of toxic amyloid-β (Aβ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease (AD). The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity; however, its role in the development of AD remains to be clarified. Th...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wang, Yan-Jiang, Wang, Xin, Lu, Jian-Jun, Li, Qiao-Xin, Gao, Chang-Yue, Liu, Xiao-Hong, Sun, Yin, Yang, Miao, Lim, Yoon, Evin, Genevieve, Zhong, Jin-Hua, Masters, Colin, Zhou, Xin-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633040/
https://ncbi.nlm.nih.gov/pubmed/21307265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2733-10.2011
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