Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted to perform a detailed model informed populati...

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Udgivet i:Front Pediatr
Main Authors: Faisal, Muhammad, Cawello, Willi, Burckhardt, Bjoern B., de Hoon, Jan, Laer, Stephanie
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pediatrics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629781/
https://ncbi.nlm.nih.gov/pubmed/31338356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2019.00281
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