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Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted to perform a detailed model informed populati...

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Detalhes bibliográficos
Publicado no:Front Pediatr
Main Authors: Faisal, Muhammad, Cawello, Willi, Burckhardt, Bjoern B., de Hoon, Jan, Laer, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629781/
https://ncbi.nlm.nih.gov/pubmed/31338356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2019.00281
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