Simultaneous Semi-Mechanistic Population Pharmacokinetic Modeling Analysis of Enalapril and Enalaprilat Serum and Urine Concentrations From Child Appropriate Orodispersible Minitablets

Enalapril is recommended as the first line of therapy and is proven to improve survival rates for treatment of Pediatric Heart Failure; however, an approved drug and child appropriate dosage formulation is still absent. The present analysis was conducted to perform a detailed model informed populati...

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Veröffentlicht in:Front Pediatr
Hauptverfasser: Faisal, Muhammad, Cawello, Willi, Burckhardt, Bjoern B., de Hoon, Jan, Laer, Stephanie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pediatrics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629781/
https://ncbi.nlm.nih.gov/pubmed/31338356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fped.2019.00281
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