The chaperonin TRiC/CCT associates with Prefoldin through a conserved electrostatic interface essential for cellular proteostasis

Maintaining proteostasis in eukaryotic protein folding involves cooperation of distinct chaperone systems. To understand how the essential ring-shaped chaperonin TRiC/CCT cooperates with the chaperone Prefoldin/GIMc (PFD) we here integrate cryoEM, crosslinking- mass-spectrometry and biochemical and...

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Publicado en:Cell
Main Authors: Gestaut, Daniel, Roh, Soung Hun, Ma, Boxue, Pintilie, Grigore, Joachimiak, Lukasz A., Leitner, Alexander, Walzthoeni, Thomas, Aebersold, Ruedi, Chiu, Wah, Frydman, Judith
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629582/
https://ncbi.nlm.nih.gov/pubmed/30955883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.03.012
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