Cigarette smoke–induced reduction of C1q promotes emphysema

Alteration of innate immune cells in the lungs can promote loss of peripheral tolerance that leads to autoimmune responses in cigarette smokers. Development of autoimmunity in smokers with emphysema is also strongly linked to the expansion of autoreactive T helper (Th) cells expressing interferon γ...

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Vydáno v:JCI Insight
Hlavní autoři: Yuan, Xiaoyi, Chang, Cheng-Yen, You, Ran, Shan, Ming, Gu, Bon Hee, Madison, Matthew C., Diehl, Gretchen, Perusich, Sarah, Song, Li-Zhen, Cornwell, Lorraine, Rossen, Roger D., Wetsel, Rick, Kimal, Rajapakshe, Coarfa, Cristian, Eltzschig, Holger K., Corry, David B., Kheradmand, Farrah
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629245/
https://ncbi.nlm.nih.gov/pubmed/31112138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124317
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