Agonistic induction of PPARγ reverses cigarette smoke–induced emphysema

The development of emphysema in humans and mice exposed to cigarette smoke is promoted by activation of an adaptive immune response. Lung myeloid dendritic cells (mDCs) derived from cigarette smokers activate autoreactive Th1 and Th17 cells. mDC-dependent activation of T cell subsets requires expres...

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Hlavní autoři: Shan, Ming, You, Ran, Yuan, Xiaoyi, Frazier, Michael V., Porter, Paul, Seryshev, Alexander, Hong, Jeong-Soo, Song, Li-zhen, Zhang, Yiqun, Hilsenbeck, Susan, Whitehead, Lawrence, Zarinkamar, Nazanin, Perusich, Sarah, Corry, David B., Kheradmand, Farrah
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934169/
https://ncbi.nlm.nih.gov/pubmed/24569375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70587
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