Cigarette smoke–induced reduction of C1q promotes emphysema

Alteration of innate immune cells in the lungs can promote loss of peripheral tolerance that leads to autoimmune responses in cigarette smokers. Development of autoimmunity in smokers with emphysema is also strongly linked to the expansion of autoreactive T helper (Th) cells expressing interferon γ...

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Udgivet i:JCI Insight
Main Authors: Yuan, Xiaoyi, Chang, Cheng-Yen, You, Ran, Shan, Ming, Gu, Bon Hee, Madison, Matthew C., Diehl, Gretchen, Perusich, Sarah, Song, Li-Zhen, Cornwell, Lorraine, Rossen, Roger D., Wetsel, Rick, Kimal, Rajapakshe, Coarfa, Cristian, Eltzschig, Holger K., Corry, David B., Kheradmand, Farrah
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629245/
https://ncbi.nlm.nih.gov/pubmed/31112138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124317
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