Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development

Mutagenic screening is powerful for identifying key genes involved in developmental processes. However, such screens are successful only in lower organisms. Here, we develop a targeted genetic screening approach in mice through combining androgenetic haploid embryonic stem cells (AG-haESCs) and clus...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Bai, Meizhu, Han, Yujiao, Wu, Yuxuan, Liao, Jiaoyang, Li, Lin, Wang, Lijun, Li, Qing, Xing, Wenhui, Chen, Luonan, Zou, Weiguo, Li, Jinsong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Methods and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629148/
https://ncbi.nlm.nih.gov/pubmed/31265461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000350
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