Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation

Mammalian haploid embryonic stem cells (haESCs) provide new possibilities for large-scale genetic screens because they bear only one copy of each chromosome. However, haESCs are prone to spontaneous diploidization through unknown mechanisms. Here, we report that a small molecule combination could re...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Li, Haisen, Guo, Ao, Xie, Zhenfei, Tu, Wanzhi, Yu, Jiali, Wang, Huihan, Zhao, Jian, Zhong, Cuiqing, Kang, Jiuhong, Li, Jinsong, Huang, Shichao, Shen, Li
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643530/
https://ncbi.nlm.nih.gov/pubmed/29038567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13471-4
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