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Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation
Mammalian haploid embryonic stem cells (haESCs) provide new possibilities for large-scale genetic screens because they bear only one copy of each chromosome. However, haESCs are prone to spontaneous diploidization through unknown mechanisms. Here, we report that a small molecule combination could re...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5643530/ https://ncbi.nlm.nih.gov/pubmed/29038567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13471-4 |
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