Antisense oligonucleotide treatment ameliorates IFN-γ–induced proteinuria in APOL1-transgenic mice

African Americans develop end-stage renal disease at a higher rate compared with European Americans due to 2 polymorphisms (G1 and G2 risk variants) in the apolipoprotein L1 (APOL1) gene common in people of African ancestry. Although this compelling genetic evidence provides an exciting opportunity...

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Vydáno v:JCI Insight
Hlavní autoři: Aghajan, Mariam, Booten, Sheri L., Althage, Magnus, Hart, Christopher E., Ericsson, Anette, Maxvall, Ingela, Ochaba, Joseph, Menschik-Lundin, Angela, Hartleib, Judith, Kuntz, Steven, Gattis, Danielle, Ahlström, Christine, Watt, Andrew T., Engelhardt, Jeffery A., Monia, Brett P., Magnone, Maria Chiara, Guo, Shuling
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629101/
https://ncbi.nlm.nih.gov/pubmed/31217349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126124
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