Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients

Biallelic inactivating mutations in DOCK8 cause a combined immunodeficiency characterized by severe pathogen infections, eczema, allergies, malignancy, and impaired humoral responses. These clinical features result from functional defects in most lymphocyte lineages. Thus, DOCK8 plays a key role in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JCI Insight
Main Authors: Pillay, Bethany A., Avery, Danielle T., Smart, Joanne M., Cole, Theresa, Choo, Sharon, Chan, Damien, Gray, Paul E., Frith, Katie, Mitchell, Richard, Phan, Tri Giang, Wong, Melanie, Campbell, Dianne E., Hsu, Peter, Ziegler, John B., Peake, Jane, Alvaro, Frank, Picard, Capucine, Bustamante, Jacinta, Neven, Benedicte, Cant, Andrew J., Uzel, Gulbu, Arkwright, Peter D., Casanova, Jean-Laurent, Su, Helen C., Freeman, Alexandra F., Shah, Nirali, Hickstein, Dennis D., Tangye, Stuart G., Ma, Cindy S.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2019
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629099/
https://ncbi.nlm.nih.gov/pubmed/31021819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127527
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים