Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing the mitochondrial oxidative respiration rate. Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending the lifespan of...

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Su, Yuan, Wang, Tao, Wu, Nan, Li, Diyan, Fan, Xiaolan, Xu, Zhongxian, Mishra, Shailendra Kumar, Yang, Mingyao
Format: Artigo
Language:Inglês
Published: Impact Journals 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
https://ncbi.nlm.nih.gov/pubmed/31242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102045
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