Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing the mitochondrial oxidative respiration rate. Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending the lifespan of...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Su, Yuan, Wang, Tao, Wu, Nan, Li, Diyan, Fan, Xiaolan, Xu, Zhongxian, Mishra, Shailendra Kumar, Yang, Mingyao
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
https://ncbi.nlm.nih.gov/pubmed/31242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102045
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