Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing the mitochondrial oxidative respiration rate. Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending the lifespan of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Su, Yuan, Wang, Tao, Wu, Nan, Li, Diyan, Fan, Xiaolan, Xu, Zhongxian, Mishra, Shailendra Kumar, Yang, Mingyao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629006/
https://ncbi.nlm.nih.gov/pubmed/31242135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102045
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