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Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
Alpha-ketoglutarate (AKG) is a key metabolite of the tricarboxylic acid (TCA) cycle, an essential process influencing the mitochondrial oxidative respiration rate. Recent studies have shown that dietary AKG reduces mTOR pathway activation by inhibiting ATP synthase, thereby extending the lifespan of...
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| Pubblicato in: | Aging (Albany NY) |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Impact Journals
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6629006/ https://ncbi.nlm.nih.gov/pubmed/31242135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102045 |
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