Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors

Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence attributed to different factors. We compared cellular intoxication by TcdB(NAP1) w...

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Veröffentlicht in:Toxins (Basel)
Hauptverfasser: López-Ureña, Diana, Orozco-Aguilar, Josué, Chaves-Madrigal, Yendry, Ramírez-Mata, Andrea, Villalobos-Jimenez, Amanda, Ost, Stefan, Quesada-Gómez, Carlos, Rodríguez, César, Papatheodorou, Panagiotis, Chaves-Olarte, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628394/
https://ncbi.nlm.nih.gov/pubmed/31212980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins11060348
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