Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B

Secreted toxin B (TcdB) substantially contributes to the pathology observed during Clostridium difficile infection. To be successfully incorporated into a vaccine, TcdB-based immunogens must stimulate the production of neutralizing antibody (Ab)-encoding memory B cells (Bmem cells). Despite numerous...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Devera, T. Scott, Lang, Gillian A., Lanis, Jordi M., Rampuria, Pragya, Gilmore, Casey L., James, Judith A., Ballard, Jimmy D., Lang, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693989/
https://ncbi.nlm.nih.gov/pubmed/26502913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00011-15
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