Difference in the Cytotoxic Effects of Toxin B from Clostridium difficile Strain VPI 10463 and Toxin B from Variant Clostridium difficile Strain 1470

Glucosylation of RhoA, Rac1, and Cdc42 by Clostridium difficile toxin B from strain VPI 10463 (TcdB) results in actin reorganization (cytopathic effect) and apoptosis (cytotoxic effect). Toxin B from variant C. difficile strain 1470 serotype F (TcdBF) differs from TcdB with regard to substrate prote...

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Detalhes bibliográficos
Main Authors: Huelsenbeck, Johannes, Dreger, Stefanie, Gerhard, Ralf, Barth, Holger, Just, Ingo, Genth, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828479/
https://ncbi.nlm.nih.gov/pubmed/17145947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01705-06
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