PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma

Uveal melanoma (UM) remains without effective therapy at the metastatic stage, which is associated with BAP-1 (BRCA1 associated protein) mutations. However, no data on DNA repair capacities in UM are available. Here, we use UM patient-derived xenografts (PDXs) to study the therapeutic activity of th...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: de Koning, Leanne, Decaudin, Didier, El Botty, Rania, Nicolas, André, Carita, Guillaume, Schuller, Mathieu, Ouine, Bérengère, Cartier, Aurélie, Naguez, Adnan, Fleury, Justine, Cooke, Vesselina, Wylie, Andrew, Smith, Paul, Marangoni, Elisabetta, Gentien, David, Meseure, Didier, Mariani, Pascale, Cassoux, Nathalie, Piperno-Neumann, Sophie, Roman-Roman, Sergio, Némati, Fariba
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628115/
https://ncbi.nlm.nih.gov/pubmed/31146482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060751
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