Targeting IRAK4 for Degradation with PROTACs

[Image: see text] Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) is a key mediator of innate immunity. IRAK4 overactivation is linked with several autoimmune diseases. To date, many IRAK4 inhibitors have been developed to block the protein’s kinase activity with the most advanced reaching Phase...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Nunes, Joao, McGonagle, Grant A., Eden, Jessica, Kiritharan, Girieshanie, Touzet, Megane, Lewell, Xiao, Emery, John, Eidam, Hilary, Harling, John D., Anderson, Niall A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2019
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627720/
https://ncbi.nlm.nih.gov/pubmed/31312412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00219
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