Targeting IRAK4 for Degradation with PROTACs

[Image: see text] Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) is a key mediator of innate immunity. IRAK4 overactivation is linked with several autoimmune diseases. To date, many IRAK4 inhibitors have been developed to block the protein’s kinase activity with the most advanced reaching Phase...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Nunes, Joao, McGonagle, Grant A., Eden, Jessica, Kiritharan, Girieshanie, Touzet, Megane, Lewell, Xiao, Emery, John, Eidam, Hilary, Harling, John D., Anderson, Niall A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627720/
https://ncbi.nlm.nih.gov/pubmed/31312412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00219
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